N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide

Base Information

Chemical Name:N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide
CAS No.:68256-12-2
Molecular Formula:C18H30N4O4S
Molecular Weight:398.5202
Hs Code.:
DSSTox Substance ID:DTXSID70987778
ChEMBL ID:CHEMBL15117

Synonyms:BRN 0454281;N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide;68256-12-2;Benzamide, 5-(((dimethylamino)sulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-;CHEMBL15117;SCHEMBL11090818;C18H30N4O4S;DTXSID70987778;LS-26670;5-[(Dimethylsulfamoyl)amino]-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-4-methylbenzene-1-carboximidic acid

Suppliers and Price of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide

Chemical Property:

Density:1.216g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:398.19877662
Heavy Atom Count:27
Complexity:593

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=C(C=C(C(=C2)NS(=O)(=O)N(C)C)C)OC

Technology Process of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide

There total 8 articles about N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-methyl-5-((dimethylsulfamoyl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90763-12-5
2-methoxy-4-methyl-5-nitrobenzoic acid

: 68256-12-2
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-methyl-5-<(dimethylsulfamoyl)amino>benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 1 h / Heating

3: 2.38 g / H₂ / PtO₂ / methanol

4: 72 percent / pyridine / 0.5 h / Ambient temperature

5: 92 percent / 10percent NaOH aq. / 0.5 h / 80 °C

6: SOCl₂ / 0.5 h / Heating

7: CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; sodium hydroxide; thionyl chloride; hydrogen; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/jm00375a009

Reference yield:

: 1057652-79-5
methyl 2-methoxy-4-methyl-5-nitrobenzoate

: 68256-12-2
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-methyl-5-<(dimethylsulfamoyl)amino>benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2.38 g / H₂ / PtO₂ / methanol

2: 72 percent / pyridine / 0.5 h / Ambient temperature

3: 92 percent / 10percent NaOH aq. / 0.5 h / 80 °C

4: SOCl₂ / 0.5 h / Heating

5: CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; sodium hydroxide; thionyl chloride; hydrogen; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/jm00375a009

Reference yield:

: 68256-33-7
2-methoxy-4-methyl-5-nitrobenzoyl chloride

: 68256-12-2
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-methyl-5-<(dimethylsulfamoyl)amino>benzamide

Guidance literature:: Multi-step reaction with 6 steps

2: 2.38 g / H₂ / PtO₂ / methanol

3: 72 percent / pyridine / 0.5 h / Ambient temperature

4: 92 percent / 10percent NaOH aq. / 0.5 h / 80 °C

5: SOCl₂ / 0.5 h / Heating

6: CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; sodium hydroxide; thionyl chloride; hydrogen; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/jm00375a009