N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide

Base Information

• Chemical Name: N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide
• CAS No.: 1088187-91-0
• Molecular Formula: C₂₂H₁₆N₂O
• Molecular Weight: 324.382
• Mol file: 1088187-91-0.mol

Synonyms:N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide

Chemical Property of N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide

There total 8 articles about N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-quinolin-8-yl-benzamide (33757-48-1) + phenylboronic acid (98-80-6) → N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide (1088187-91-0)

Guidance literature:

With sodium carbonate; silver carbonate; cobalt acetylacetonate; In dimethyl sulfoxide; at 120 ℃; for 2h; Schlenk technique; Sealed tube;

DOI:10.1039/c6ob02224c

Reference yield: 76.0%

iodobenzene (591-50-4) + N-quinolin-8-yl-benzamide (33757-48-1) → N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide (1088187-91-0)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); mesitylenecarboxylic acid; sodium carbonate; In 1,4-dioxane; at 140 ℃; for 24h;

DOI:10.1039/c5sc00268k

Reference yield: 70.0%

N-quinolin-8-yl-benzamide (33757-48-1) + phenyl trimethylsiloxane (2996-92-1,46143-12-8) → N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide (1088187-91-0)

Guidance literature:

With copper (II)-fluoride; cobalt(II) acetate; cesium fluoride; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 20h; Temperature; Solvent; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201806114

upstream raw materials:

N-quinolin-8-yl-benzamide

phenylmagnesium bromide

4-(benzoyloxy)morpholine

N-(2-naphthalenecarbonyl)-8-aminoquinoline