rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

Base Information

Chemical Name:rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate
CAS No.:1609081-89-1
Molecular Formula:C₂₅H₂₀ClF₂N₃O₄
Molecular Weight:499.901
Hs Code.:

Synonyms:rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

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Chemical Property of rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

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Technology Process of rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

There total 6 articles about rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1415501-19-7
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid

: 43189-20-4
methyl (±)-2-amino-2-(4-chlorophenyl)acetate

: 1609081-89-1
rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; at 20 ℃;

Reference yield: 72.0%

: 1609081-89-1
rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1609081-89-1
rac-methyl (4-chlorophenyl)[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / 20 °C

With 4-methyl-morpholine; water; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;