5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one

Base Information

• Chemical Name: 5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one
• CAS No.: 135159-05-6
• Molecular Formula: C₂₇H₂₆O₈
• Molecular Weight: 478.499
• Mol file: 135159-05-6.mol

Synonyms:5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one

Chemical Property of 5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one

There total 1 articles about 5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3'-iodo-5,7,4'-trimethoxyflavone (3754-52-7) + (2,4,6-trimethoxyphenyl)boronic acid (135159-25-0) → 5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one (135159-05-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; for 5h; Heating;

DOI:10.1016/S0040-4039(00)79688-2

Reference yield: 76.0%

(E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) + 5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one (135159-05-6) → 2-{2'-Hydroxy-6,4',6'-trimethoxy-3'-[(E)-3-(4-methoxy-phenyl)-acryloyl]-biphenyl-3-yl}-5,7-dimethoxy-chromen-4-one (135159-06-7)

Guidance literature:

With boron trifluoride diethyl etherate; at 70 ℃;

DOI:10.1016/S0040-4039(00)79688-2

Reference yield:

5,7-Dimethoxy-2-(6,2',4',6'-tetramethoxy-biphenyl-3-yl)-chromen-4-one (135159-05-6) → Amentoflavon (3778-26-5,22783-10-4,78511-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / BF₃*Et₂O / 70 °C

2: 87 percent / I₂, H₂SO₄ conc. / dimethylsulfoxide / 20 h / 100 °C

With sulfuric acid; boron trifluoride diethyl etherate; iodine; In dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)79688-2

upstream raw materials:

3'-iodo-5,7,4'-trimethoxyflavone

(2,4,6-trimethoxyphenyl)boronic acid

Downstream raw materials:

2-{2'-Hydroxy-6,4',6'-trimethoxy-3'-[(E)-3-(4-methoxy-phenyl)-acryloyl]-biphenyl-3-yl}-5,7-dimethoxy-chromen-4-one

Amentoflavon