(R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile

Base Information

Chemical Name:(R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile
CAS No.:1380297-58-4
Molecular Formula:C₁₈H₁₁BrCl₂F₃NO
Molecular Weight:465.097
Hs Code.:

Synonyms:(R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile

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Technology Process of (R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile

There total 1 articles about (R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1154739-81-7
(E)-1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-en-1-one

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1380297-58-4
(R)-4-(4-bromo-3-methylphenyl)-2-(3,5-dichlorophenyl)-4-oxo-2-(trifluoromethyl)butanenitrile

Guidance literature:: With N-[2,5-bis(trifluoromethyl)benzyl]-O-methylquinidinium bromide; caesium carbonate; In di-isopropyl ether; at 0 ℃; for 10h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201201278