8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Base Information

Chemical Name:8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
CAS No.:120420-53-3
Molecular Formula:C₁₃H₁₂FNO₃
Molecular Weight:249.242
Hs Code.:

Synonyms:8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Technology Process of 8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 2 articles about 8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.5%

: 348-54-9
2-Fluoroaniline

: 570-08-1
diethyl acetylmalonate

: 399-31-5
N-(2-fluorophenyl)acetamide

: 120420-53-3
8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 105-53-3
diethyl malonate

Guidance literature:: With hydrogenchloride; 1.)20-100 mg Hg, 45-50 deg C, 16 h 2.)190-220 deg C, 0.5 h;
DOI:10.1007/BF00633172

Reference yield:

: 348-54-9
2-Fluoroaniline

: 570-08-1
diethyl acetylmalonate

: 399-31-5
N-(2-fluorophenyl)acetamide

: 120420-53-3
8-Fluoro-2-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 105-53-3
diethyl malonate

Guidance literature:: With hydrogenchloride; In benzene; for 16h; Product distribution; Heating; product yield/distribution vs. basicity of educt;
DOI:10.1007/BF00633172