(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1228968-86-2
Molecular Formula:C₃₈H₄₄N₆O₄
Molecular Weight:648.805
Hs Code.:

(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Synonyms:(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 7 articles about (S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1228552-62-2
(S)-2-(4-iodo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1228968-85-1
C₂₆H₂₇N₃O₂

: 1228968-86-2
(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;

Reference yield:

: 1228968-84-0
C₂₉H₃₅N₃O₂Si

: 1228968-86-2
(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / tetrahydrofuran / 3 h / 20 °C

2: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

With piperidine; methanol; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1228968-83-9
tert-butyl (2S)-2-[5-(4'-bromobiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

: 1228968-86-2
(S)-tert-butyl 2-(5-((4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine / tetrahydrofuran / Inert atmosphere; Reflux

2: methanol; potassium carbonate / tetrahydrofuran / 3 h / 20 °C

3: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

With piperidine; methanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;