2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione
CAS No.:881686-00-6
Molecular Formula:C₂₇H₃₂N₂O₃
Molecular Weight:432.563
Hs Code.:

Synonyms:2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

There total 3 articles about 2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 881685-99-0
(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-amine

: 85-44-9
phthalic anhydride

: 881686-00-6
2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: In toluene; Heating;
DOI:10.1021/jm058264p

Reference yield:

: 881685-98-9
(1R,4S,5R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-one oxime

: 881686-00-6
2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Na; isopropanol / toluene / Heating

2: 62 percent / toluene / Heating

With sodium; isopropyl alcohol; In toluene;
DOI:10.1021/jm058264p

Reference yield:

: 444904-04-5
(-)-(1R,4S,5S)-5-[3-(1-methylethoxy)phenyl]-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-one

: 881686-00-6
2-[(1R,4S,5R,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating

2: 95 percent / Na; isopropanol / toluene / Heating

3: 62 percent / toluene / Heating

With hydroxylamine hydrochloride; sodium; isopropyl alcohol; In ethanol; toluene;
DOI:10.1021/jm058264p