methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

Base Information

Chemical Name:methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate
CAS No.:1416000-60-6
Molecular Formula:C₂₆H₂₇ClF₃N₅O₄
Molecular Weight:565.98
Hs Code.:

Synonyms:methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

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Chemical Property of methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

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Technology Process of methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

There total 5 articles about methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.1%

: 193902-87-3
tert-butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1416000-60-6
methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

Guidance literature:: With potassium carbonate; In dichloromethane; tert-butyl alcohol; at 20 ℃; for 24h;

Reference yield:

: 4487-59-6
2-bromo-5-nitropyridine

: 1416000-60-6
methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: iron; hydrogenchloride / ethanol; water / 5 h / Reflux

2: ethanol / 5 h / Reflux

3: diphenylether / 0.75 h / Reflux

4: dimethyl amine; trichlorophosphate / 3 h / Reflux

5: potassium carbonate / tert-butyl alcohol; dichloromethane / 24 h / 20 °C

With hydrogenchloride; iron; potassium carbonate; dimethyl amine; trichlorophosphate; In diphenylether; ethanol; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 13534-97-9
6-bromopyridine-3-amine

: 1416000-60-6
methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 5 h / Reflux

2: diphenylether / 0.75 h / Reflux

3: dimethyl amine; trichlorophosphate / 3 h / Reflux

4: potassium carbonate / tert-butyl alcohol; dichloromethane / 24 h / 20 °C

With potassium carbonate; dimethyl amine; trichlorophosphate; In diphenylether; ethanol; dichloromethane; tert-butyl alcohol;