2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

Base Information

Chemical Name:2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one
CAS No.:1415999-78-8
Molecular Formula:C₂₈H₂₃F₃N₆O₂
Molecular Weight:532.525
Hs Code.:

Synonyms:2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

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Chemical Property of 2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

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Technology Process of 2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

There total 9 articles about 2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

: 1416000-69-5
tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

: 1415999-78-8
2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

Guidance literature:: With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1415999-78-8
2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tert-butyl alcohol; dichloromethane / 24 h / 20 °C

2: sodium tetrahydroborate; ethanol / 18 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 3 h / 20 °C

4: N,N-dimethyl acetamide / 0.67 h / 160 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / Inert atmosphere; Reflux

6: hydrogenchloride / dichloromethane / 0.5 h

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium carbonate; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl acetamide; toluene; tert-butyl alcohol;

Reference yield:

: 1416000-64-0
tert-butyl 4-(4-((6-chloro-3-formyl-1,5-naphthyridin-4-yl)amino)-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate

: 1415999-78-8
2-(6-methoxypyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tert-butyl alcohol / 36 h / 160 °C / Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / Inert atmosphere; Reflux

3: hydrogenchloride / dichloromethane / 0.5 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; dichloromethane; toluene; tert-butyl alcohol;