(R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

Base Information

Chemical Name:(R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide
CAS No.:68709-61-5
Molecular Formula:C₂₅H₂₃Cl₂N₃O₃
Molecular Weight:484.382
Hs Code.:

Synonyms:(R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

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Chemical Property of (R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

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Technology Process of (R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

There total 8 articles about (R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 68709-61-5
(R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / DCC, N-hydroxysuccinimide / dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

2: 51 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

3: 21.8percent HBr / acetic acid / 1.5 h / Ambient temperature

With chromium(VI) oxide; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00181a013

Reference yield:

: 59180-06-2
{(R)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

: 68709-61-5
(R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

Guidance literature:: With hydrogen bromide; In acetic acid; for 1.5h; Yield given; Ambient temperature;
DOI:10.1021/jm00181a013

Reference yield:

: 24107-07-1
ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

: 68709-61-5
(R)-2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

3: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

4: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

5: 75 percent / DCC, N-hydroxysuccinimide / dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

6: 51 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

7: 21.8percent HBr / acetic acid / 1.5 h / Ambient temperature

With chromium(VI) oxide; potassium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; thionyl chloride; ammonia; hydrogen bromide; sodium hydride; dicyclohexyl-carbodiimide; In diethyl ether; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00181a013