(+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline

Base Information

• Chemical Name: (+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline
• CAS No.: 862259-18-5
• Molecular Formula: C₁₅H₂₂O₂Si
• Molecular Weight: 262.424
• Mol file: 862259-18-5.mol

Synonyms:(+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline

Chemical Property of (+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline

There total 2 articles about (+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(+/-)-1-benzyloxy-hex-4-yn-2-ol (189504-80-1) + 1,1,3,3-tetramethyldisilazane (15933-59-2) → (+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline (862259-18-5)

Guidance literature:

(+/-)-1-benzyloxy-hex-4-yn-2-ol; 1,1,3,3-tetramethyldisilazane; at 50 ℃; for 2h;

With tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/ja051578h

Reference yield:

Benzyloxymethyl-oxiran (2930-05-4) → (+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline (862259-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; toluene / 0 °C

1.2: diethylaluminium chloride / toluene; tetrahydrofuran / 4.5 h / 0 °C

1.3: toluene; tetrahydrofuran / 10.5 h / 0 °C

2.1: 2 h / 50 °C

2.2: 90 percent / [Cp*Ru(MeCN)3]PF₆ / CH₂Cl₂ / 2 h / 0 - 20 °C

With n-butyllithium; In tetrahydrofuran; toluene;

DOI:10.1021/ja051578h

Reference yield:

(+/-)-6-benzyloxymethyl-2,2,3-trimethyl-5,6-dihydro-2H-[1,2]oxasiline (862259-18-5) → (1S,4S,6R)-4-Benzyloxymethyl-1,2,2-trimethyl-3,7-dioxa-2-sila-bicyclo[4.1.0]heptane

Guidance literature:

With DMDO; In acetone; at -78 - -20 ℃; for 2h;

DOI:10.1021/ja051578h

upstream raw materials:

(+/-)-1-benzyloxy-hex-4-yn-2-ol

1,1,3,3-tetramethyldisilazane

Benzyloxymethyl-oxiran