Benzyl glycidyl ether

Base Information

• Chemical Name: Benzyl glycidyl ether
• CAS No.: 2930-05-4
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 29329990
• European Community (EC) Number: 920-007-0
• DSSTox Substance ID: DTXSID001019317
• Nikkaji Number: J64.257F
• Mol file: 2930-05-4.mol

Synonyms:Benzyl glycidyl ether;2930-05-4;2-((Benzyloxy)methyl)oxirane;2-[(benzyloxy)methyl]oxirane;89616-40-0;Oxirane, [(phenylmethoxy)methyl]-;2-(phenylmethoxymethyl)oxirane;(Benzyloxymethyl)oxirane;2-(Benzyloxymethyl)oxirane;Propane, 1-(benzyloxy)-2,3-epoxy-;1-(Benzyloxy)-2,3-epoxypropane;((Phenylmethoxy)methyl)oxirane;Oxirane, ((phenylmethoxy)methyl)-;EINECS 220-899-5;BRN 0115279;[(Phenylmethoxy)methyl]oxirane (Benzyl Glycidyl Ether);(S)-(+)-Glycidyl Benzyl Ether;MFCD00054428;benzyl-glycidylether;benzyloxymethyloxirane;benzyl-glycidyl ether;glycidyl benzyl ether;Oxirane, 2-[(phenylmethoxy)methyl]-;2-benzyloxymethyloxirane;2-Benzyloxymethyl-oxirane;(RS)-benzyloxymethyloxirane;Benzyl glycidyl ether, 99%;2,3-epoxypropyl benzyl ether;SCHEMBL153049;3-benzyloxy-1,2-epoxypropane;1-Benzyloxy-2,3-epoxypropane;[(phenylmethoxy)methyl]-oxirane;DTXSID001019317;BCP26775;JX 011;MFCD00068664;STK029823;racemic 2-[(benzyloxy)methyl]oxirane;AKOS000200901;AKOS016051438;(+/-)-2-(phenylmethoxymethyl)oxirane;AM84897;CS-W008783;DS-3160;SY007924;SY021000;LS-119619;B2108;FT-0601498;FT-0601499;FT-0688170;FT-0689652;EN300-09423;J-017470;Z56346889;F1791-1205

Chemical Property of Benzyl glycidyl ether

Chemical Property:

• Melting Point: 89.5-90.1 °C
• Refractive Index: n20/D 1.5170(lit.)
• Boiling Point: 252.7 °C at 760 mmHg
• Flash Point: 100.9 °C
• PSA: 21.76000
• Density: 1.102 g/cm³
• LogP: 1.60200
• Storage Temp.: Refrigerator
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

98%,99%, ^*data from raw suppliers

[(Phenylmethoxy)methyl]oxirane(BenzylGlycidylEther) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(O1)COCC2=CC=CC=C2
• Uses: [(Phenylmethoxy)methyl]oxirane, is a Glycidol (G615700) derivative. It is also shown that analougues of Phenyl Glycidyl Ether has in Vivo skin sensitizing potency, and is able to induce Nrf2-Dependent Luciferase Activity in the KeratinoSens.

Technology Process of Benzyl glycidyl ether

There total 78 articles about Benzyl glycidyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl allyl ether (14593-43-2) → Benzyloxymethyl-oxiran (2930-05-4)

Guidance literature:

With rhenium trioxide; bis-trimethylsilanyl peroxide; water; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1021/jo010369m

Reference yield: 95.0%

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) + benzyl alcohol (100-51-6,185532-71-2) → Benzyloxymethyl-oxiran (2930-05-4)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; for 2.5h;

DOI:10.1021/jo00222a030

Reference yield: 92.0%

1-chloro-2-hydroxy-3-phenylmethoxypropane (13991-52-1,103024-85-7) → Benzyloxymethyl-oxiran (2930-05-4)

Guidance literature:

With sodium hydroxide; at 5 ℃;

DOI:10.1021/jo00156a018

upstream raw materials:

3-benzyloxypropan-1,2-diol

benzyl allyl ether

glycidyl p-toluenesulfonate

sodium phenyl-methanolate

Downstream raw materials:

(2S)-1-(Phenylmethoxy)-4-(phenylsulfonyl)-5-(trimethylsilyl)-2-pentanol

(3S,5S)-5-Benzyloxymethyl-3-methyl-dihydro-furan-2-one

(3R,5S)-5-Benzyloxymethyl-3-methyl-dihydro-furan-2-one

(S)-5-Benzyloxy-4-hydroxy-1-pentyne

Refernces

• 1、 Cheshkov, D. A.,Khrulev, A. A.,Maslov, M. A.,Morozova, N. G.,Nichugovskiy, A. I.,Perevoshchikova, K. A.. "Synthesis of Isonitrile Derivatives of Diglycerides and Carbohydrates as Intermediates for Multicomponent Ugi Reaction". . p. 929 - 938. Retrieved 2021/08/25.
• 2、 Fujitani, Tadahiro,Hong, Dachao,Ito, Satoru,Ji, Xinyi,Kon, Yoshihiro,Nakashima, Takuya,Osuga, Ryota,Sato, Kazuhiko,Yokoi, Toshiyuki. "Chemoselective Epoxidation of Allyloxybenzene by Hydrogen Peroxide Over MFI-Type Titanosilicate". supporting information. . Retrieved 2020/04/15.