2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

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Chemical Name:2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid
CAS No.:1616484-44-6
Molecular Formula:C₁₇H₁₅N₇O₂
Molecular Weight:349.352
Hs Code.:

Synonyms:2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

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Chemical Property of 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

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Technology Process of 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

There total 3 articles about 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1616484-36-6
ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

: 1616484-44-6
2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1039/c4ob00904e

Reference yield:

: 1616484-24-2
ethyl 2-(4-amino-5-((trimethylsilyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

: 1616484-44-6
2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Amberlite? IRA 900 F^-form / chloroform / 18 h / 20 °C / Inert atmosphere

2.1: sodium azide / water / 140 °C / Microwave irradiation

2.2: 18 h / 20 °C / Sealed tube; Inert atmosphere

3.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

With sodium azide; water; lithium hydroxide; In tetrahydrofuran; chloroform; water;
DOI:10.1039/c4ob00904e

Reference yield:

: 163622-50-2
4-amino-5-iodo-7H-pyrrolo[2,3‐d]pyrimidine

: 1616484-44-6
2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Sealed tube; Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Sealed tube; Inert atmosphere

3.1: Amberlite? IRA 900 F^-form / chloroform / 18 h / 20 °C / Inert atmosphere

4.1: sodium azide / water / 140 °C / Microwave irradiation

4.2: 18 h / 20 °C / Sealed tube; Inert atmosphere

5.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; water; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00904e