ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

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Chemical Name:ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate
CAS No.:1616484-36-6
Molecular Formula:C₁₉H₁₉N₇O₂
Molecular Weight:377.406
Hs Code.:

Synonyms:ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

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Chemical Property of ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

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Technology Process of ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

There total 2 articles about ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1616484-26-4
ethyl 2-(4-amino-5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

: 100-39-0
benzyl bromide

: 1616484-36-6
ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

Guidance literature:: benzyl bromide; With sodium azide; In water; at 140 ℃; Microwave irradiation;

ethyl 2-(4-amino-5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate; With triethylamine; In ethyl acetate; at 20 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1039/c4ob00904e

Reference yield:

: 163622-50-2
4-amino-5-iodo-7H-pyrrolo[2,3‐d]pyrimidine

: 1616484-36-6
ethyl 2-(4-amino-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Sealed tube; Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Sealed tube; Inert atmosphere

3.1: Amberlite? IRA 900 F^-form / chloroform / 18 h / 20 °C / Inert atmosphere

4.1: sodium azide / water / 140 °C / Microwave irradiation

4.2: 18 h / 20 °C / Sealed tube; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; caesium carbonate; triethylamine; In chloroform; water; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00904e