(E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide

Base Information

• Chemical Name: (E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide
• CAS No.: 591249-57-9
• Molecular Formula: C₃₁H₃₇NO₃S
• Molecular Weight: 503.706

Synonyms:(E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide

Chemical Property of (E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide

Chemical Property:

Purity/Quality:

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Technology Process of (E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide

There total 2 articles about (E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2-benzhydryl-1,1-dioxo-1λ6-isothiazolidin-5-yl)-hydroxy-methyl]-2,6-di-tert-butyl-phenol → (E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide (591249-57-9)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In ethyl acetate; at 0 ℃;

DOI:10.1016/S0968-0896(03)00141-X

Reference yield:

2-benzhydryl-1,2-isothiazolidine 1,1-dioxide (591249-56-8) → (E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide (591249-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LHMDS / tetrahydrofuran / -78 °C

2: methansulfonyl chloride; triethylamine / ethyl acetate / 0 °C

With methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/S0968-0896(03)00141-X

Reference yield: 95.0%

(E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide (591249-57-9) → (E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide (158090-19-8)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h;

DOI:10.1016/S0968-0896(03)00141-X

upstream raw materials:

2-benzhydryl-1,2-isothiazolidine 1,1-dioxide

Downstream raw materials:

(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

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