(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

Base Information

Chemical Name:(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide
CAS No.:158090-19-8
Molecular Formula:C₁₈H₂₇NO₃S
Molecular Weight:337.483
Hs Code.:

Synonyms:(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

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Technology Process of (E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

There total 9 articles about (E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 591249-57-9
(E)-2-benzhydryl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1,2-isothiazolidine 1,1-dioxide

: 158090-19-8
(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h;
DOI:10.1016/S0968-0896(03)00141-X

Reference yield: 41.0%

: 279669-73-7
2,6-di-tert-butyl-4-[2-(4-methoxy-benzyl)-1,1-dioxo-1λ⁶-isothiazolidin-5-ylidenemethyl]-phenol

: 2,6-di-tert-butyl-4-(1,1-dioxo-1λ⁶-isothiazolidin-5-ylidenemethyl)-phenol

: 158090-19-8
(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jm9906015

Reference yield:

: 74222-81-4
2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane

: 158090-19-8
(E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)isothiazolidine 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.17 h

1.2: 80 percent / tetrahydrofuran; dimethylformamide / 1 h

2.1: 100 percent / aq. HCl / acetone / 1 h

3.1: diisopropylamine; BuLi; hexamethylphosphamide / hexane; tetrahydrofuran / 0.5 h / -78 °C

4.1: p-TsOH / toluene / 0.5 h / Heating

5.1: 41 percent / TiCl₄ / CH₂Cl₂ / 0.5 h / 0 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; titanium tetrachloride; sodium hydride; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Addition / 4.1: Dehydration / 5.1: debenzylation;
DOI:10.1021/jm9906015