N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

Base Information

Chemical Name:N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester
CAS No.:169318-08-5
Molecular Formula:C₂₇H₃₈ClN₅O₅
Molecular Weight:548.082
Hs Code.:

Synonyms:N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

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Chemical Property of N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

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Technology Process of N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

There total 6 articles about N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoic acid

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 144313-55-3,200616-62-2
L-glutamic acid di-tert-butyl ester hydrochloride

: 169318-08-5
N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

Guidance literature:: With 4-methyl-morpholine; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 619-44-3
methyl 4-iodobenzoate

: 169318-08-5
N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / PdCl₂, diethylamine

2: 95 percent / H₂ / Pd/C / methanol

3: 40 percent / diethyl azodicarboxylate / tetrahydrofuran

4: 68 percent / 2-methyl-propan-2-ol

5: NaOH

6: phosphorous oxychloride, dimethylaniline / Heating

7: 2-chloro-4,6-dimethoxy-1,3,5-triazine / dimethylformamide

With sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; diethylamine; 2,3-Dimethylaniline; palladium dichloride; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/0960-894X(96)00053-4

Reference yield:

: 61266-36-2
methyl 4-(3-hydroxypropynyl)benzoate

: 169318-08-5
N-{[4-(2,6-diamino-4-chloro-5-pyrimidinyl)propyl]benzoyl}-L-glutamic acid di-t-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / H₂ / Pd/C / methanol

2: 40 percent / diethyl azodicarboxylate / tetrahydrofuran

3: 68 percent / 2-methyl-propan-2-ol

4: NaOH

5: phosphorous oxychloride, dimethylaniline / Heating

6: 2-chloro-4,6-dimethoxy-1,3,5-triazine / dimethylformamide

With sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; 2,3-Dimethylaniline; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/0960-894X(96)00053-4