Chemical Property of 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Chemical Property:
- Appearance/Colour:white to almost white crystalline powder
- Vapor Pressure:0.00152mmHg at 25°C
- Melting Point:71-74 °C(lit.)
- Refractive Index:1.512
- Boiling Point:305.1 °C at 760 mmHg
- PKA:0.33±0.10(Predicted)
- Flash Point:138.3 °C
- PSA：57.13000
- Density:1.36 g/cm3
- LogP:0.54220
- Storage Temp.:Refrigerator, Under Inert Atmosphere
- Solubility.:Chloroform, Methanol
- Water Solubility.:insoluble
- XLogP3:1.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:175.0148541
- Heavy Atom Count:11
- Complexity:114
- Purity/Quality:
-
99% min *data from raw suppliers
2-Chloro-4,6-dimethoxy-1,3,5-triazine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36/37-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=NC(=NC(=N1)Cl)OC
-
Uses
2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines. 2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:The specific labeling of streptavidin by the modular method for affinity labeling (MoAL). The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines. The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.
