2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

Base Information

Chemical Name:2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one
CAS No.:1610379-27-5
Molecular Formula:C₂₇H₂₉N₅O₂
Molecular Weight:455.56
Hs Code.:

Synonyms:2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

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Chemical Property of 2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

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Technology Process of 2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

There total 8 articles about 2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1610379-44-6
6-(4-isopropylpiperazin-1-yl)picolinaldehyde

: 1610379-26-4
3-amino-5-methoxy-[1,1'-biphenyl]-4-carboxamide

: 1610379-27-5
2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; at 120 ℃; for 72h;

Reference yield:

: 123843-67-4
4-bromo-2,6-difluorobenzonitrile

: 1610379-27-5
2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; methanol / 16 h / 0 - 20 °C

2.1: sodium carbonate / toluene / 0.17 h / 0 °C / Inert atmosphere

2.2: 18 h / 80 °C / Inert atmosphere; Sealed tube

3.1: ammonia / hexane; dimethyl sulfoxide / 18 h / 150 °C / Autoclave

4.1: potassium hydroxide / ethanol / 36 h / 100 °C / Sealed tube

5.1: sodium hydrogensulfite; toluene-4-sulfonic acid / 72 h / 120 °C

With ammonia; sodium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dimethyl sulfoxide; toluene;

Reference yield:

: 1610379-55-9
3-fluoro-5-methoxy-[1,1'-biphenyl]-4-carbonitrile

: 1610379-27-5
2-(6-(4-isopropylpiperazin-1-yl)pyridin-2-yl)-5-methoxy-7-phenylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / hexane; dimethyl sulfoxide / 18 h / 150 °C / Autoclave

2: potassium hydroxide / ethanol / 36 h / 100 °C / Sealed tube

3: sodium hydrogensulfite; toluene-4-sulfonic acid / 72 h / 120 °C

With ammonia; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide; In ethanol; hexane; dimethyl sulfoxide;