Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

Base Information

Chemical Name:Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll
CAS No.:267001-37-6
Molecular Formula:C₇₅H₁₁₄N₆O₁₆Si₂
Molecular Weight:1411.93
Hs Code.:

Synonyms:Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

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Chemical Property of Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

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Technology Process of Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

There total 10 articles about Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221451-11-2
(3aR,4S,6aS)-5-(((9H-fluoren-9-yl)methoxy)carbonyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole-4-carboxylic acid

: Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

: 267001-37-6
Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

Guidance literature:: With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jo991523w

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 267001-37-6
Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

Guidance literature:: Multi-step reaction with 7 steps

1.1: Cs₂CO₃ / methanol / 2 h / 20 °C

1.2: 94 percent / dimethylformamide / 18 h / 20 °C

2.1: Et₂NH / acetonitrile / 0.5 h / 20 °C

3.1: 800 mg / BOP; N-methylmorpholine / CH₂Cl₂ / 72 h / 20 °C

4.1: Et₂NH / acetonitrile / 0.5 h / 20 °C

5.1: 116 mg / Et₃N; BOP / CH₂Cl₂ / 3.5 h / 20 °C

6.1: Et₂NH / acetonitrile / 0.5 h / 20 °C

7.1: 55 mg / DIPEA; BroP / CH₂Cl₂ / 48 h / 20 °C

With 4-methyl-morpholine; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile; 1.1: Metallation / 1.2: Esterification / 2.1: Substitution / 3.1: Condensation / 4.1: Substitution / 5.1: Condensation / 6.1: Substitution / 7.1: Condensation;
DOI:10.1021/jo991523w

Reference yield:

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 267001-37-6
Fmoc-DHP[O2CH(CH3)2]-Hyp(O-t-Bu)-Thr(O-t-Bu)-DOPA(OTBS)2-Lys(ε-Boc)-OAll

Guidance literature:: Multi-step reaction with 7 steps

1: DCC / CH₂Cl₂ / 0 - 20 °C

2: 704 mg / DIPEA / dimethylformamide / 17 h / 0 - 20 °C

3: 800 mg / BOP; N-methylmorpholine / CH₂Cl₂ / 72 h / 20 °C

4: Et₂NH / acetonitrile / 0.5 h / 20 °C

5: 116 mg / Et₃N; BOP / CH₂Cl₂ / 3.5 h / 20 °C

6: Et₂NH / acetonitrile / 0.5 h / 20 °C

7: 55 mg / DIPEA; BroP / CH₂Cl₂ / 48 h / 20 °C

With 4-methyl-morpholine; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Esterification / 2: Condensation / 3: Condensation / 4: Substitution / 5: Condensation / 6: Substitution / 7: Condensation;
DOI:10.1021/jo991523w