Fmoc-Thr(tBu)-OH

Base Information Edit

Chemical Name:Fmoc-Thr(tBu)-OH
CAS No.:71989-35-0
Molecular Formula:C23H27NO5
Molecular Weight:397.471
Hs Code.:29242990
European Community (EC) Number:276-261-1
DSSTox Substance ID:DTXSID501218229
Nikkaji Number:J295.110J
Wikidata:Q76324350
Mol file:71989-35-0.mol

Synonyms:Fmoc-Thr(tBu)-OH;71989-35-0;Fmoc-O-tert-butyl-L-threonine;Fmoc-Thr(t-Bu)-OH;N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine;MFCD00077075;N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-threonine;EINECS 276-261-1;(2S,3R)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid;Fmoc-O-tert.butyl-L-threonine;Fmoc-Thr(OtBu)-OH;N-((9H-Fluoren-9-ylmethoxy)carbonyl)-O-isopropyl-L-threonine;N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-isopropyl-L-threonine;9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-THEONINE;SCHEMBL1738651;Fmoc-O-(tert-Butyl)-L-Thr-OH;LZOLWEQBVPVDPR-VLIAUNLRSA-N;DTXSID501218229;Nalpha-Fmoc-O-tert-butyl-L-threonine;O-tert-Butyl-Nalpha-Fmoc-L-threonine;(2S,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid;AKOS015840843;AM82252;CS-W007706;HY-W007706;(2S,3R)-2-(((9-Fluorenylmethoxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid;AS-14178;F0505;Fmoc-Thr(tBu)-OH, >=98.0% (HPLC);EN300-249917;M03389;N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylthreonine;N-9-Fluorenylmethyloxycarbonyl-O-t-butyl-L-threonine;Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-threonine;L-Threonine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;(2S,3R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-tert-butoxybutanoic acid;N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-threonine (Fmoc-L-Thr(OtBu)-OH)

Suppliers and Price of Fmoc-Thr(tBu)-OH

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-O-tert-butyl-L-threonine 98+%
5g
$ 159.00

TRC
Fmoc-Thr(tBu)-OH
2.5g
$ 65.00

TCI Chemical
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-threonine >98.0%(T)(HPLC)
5g
$ 27.00

TCI Chemical
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-threonine >98.0%(T)(HPLC)
1g
$ 14.00

TCI Chemical
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-threonine >98.0%(T)(HPLC)
25g
$ 90.00

SynQuest Laboratories
Fmoc-O-tert-Butyl-L-threonine
500 g
$ 533.00

SynQuest Laboratories
Fmoc-O-tert-Butyl-L-threonine
1 kg
$ 986.00

SynQuest Laboratories
Fmoc-O-tert-Butyl-L-threonine
100 g
$ 276.00

Sigma-Aldrich
Fmoc-Thr(tBu)-OH Novabiochem?
100 g
$ 229.00

Sigma-Aldrich
Fmoc-Thr(tBu)-OH ≥98.0% (HPLC)
100 g
$ 225.00

Total 169 raw suppliers

Chemical Property of Fmoc-Thr(tBu)-OH Edit

Chemical Property:

Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:2.24E-14mmHg at 25°C
Melting Point:131-134 °C
Refractive Index:15 ° (C=1, AcOEt)
Boiling Point:581.7 °C at 760 mmHg
PKA:3.42±0.10(Predicted)
Flash Point:305.6 °C
PSA：84.86000
Density:1.197 g/cm³
LogP:4.57280
Storage Temp.:2-8°C
Solubility.:almost transparency in Ethylacetate
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:397.18892296
Heavy Atom Count:29
Complexity:564

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-O-tert-butyl-L-threonine 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,N
Statements: 36/37/38-50/53
Safety Statements: 24/25-36/37/39-27-26-61-60-29/56

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)OC(C)(C)C
Isomeric SMILES:C[C@H]([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)OC(C)(C)C

Technology Process of Fmoc-Thr(tBu)-OH

There total 12 articles about Fmoc-Thr(tBu)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4378-13-6,201353-89-1
(O-tert-butyl)-L-threonine

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

Guidance literature:: With triethylamine; In water; acetonitrile; for 1h;

Reference yield: 67.0%

: (2S,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

Guidance literature:: With magnesium bromide; In dichloromethane; for 3h; Ambient temperature; addition at -20 deg C, 0.5 h;
DOI:10.1016/S0040-4039(97)00863-0

Reference yield:

: 67-56-1
methanol

: 72-19-5,134357-96-3,7013-32-3,82822-12-6
L-threonine

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 115-11-7,15220-85-6
isobutene

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

Guidance literature:: methanol; L-threonine; With thionyl chloride; at 40 - 45 ℃; for 20h;

isobutene; With sulfuric acid; In dichloromethane; at 0 - 5 ℃;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; Further stages;