(R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Base Information

Chemical Name:(R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol
CAS No.:441768-86-1
Molecular Formula:C₂₁H₃₅NO₄SSi
Molecular Weight:425.665
Hs Code.:

Synonyms:(R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Suppliers and Price of (R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

There total 9 articles about (R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[4-(9-bora-bicyclo[3.3.1]non-9-yl)-1-(tert-butyl-dimethyl-silanyloxy)-butyl]-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

: 441768-86-1
(R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In ethanol; for 1h; Heating;
DOI:10.1021/jo025589u

Reference yield:

: 29783-26-4
cis-4-cyclopentene-1,3-diol

: 441768-86-1
(R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 1 h / 60 °C

2: 17.89 g / Et₃N; tris(dibenzylideneacetone)dipalladium⁽⁰⁾*CHCl₃; (1R,2R)-(+)-1,2-[NHC(O)(o-(PPh₂)C₆H₄]2-cyclohexane / tetrahydrofuran / -50 - 20 °C

3: 98 percent / KOH / methanol / 2 h / 70 °C

4: 99 percent / K₂CO₃ / dimethylformamide / 20 °C

5: 98 percent / 2,6-lutidine / CH₂Cl₂ / 20 °C

6: 98 percent / Cl₂(PCy₃)2RuCHPh; ethylene; Pb(OAc)4 / CH₂Cl₂ / 14 h / 20 °C

7: tetrahydrofuran / 8 h / 0 - 55 °C

8: 2.19 g / aq. NaOH; aq. H₂O₂ / ethanol / 1 h / Heating

With 2,6-dimethylpyridine; lead(IV) acetate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium hydroxide; sodium hydroxide; Grubbs catalyst first generation; ethene; dihydrogen peroxide; potassium carbonate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo025589u

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 441768-86-1
(R)-4-(tert-butyldimethylsilanyloxy)-4-[(S)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-2-yl]butan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 1 h / 60 °C

2: 17.89 g / Et₃N; tris(dibenzylideneacetone)dipalladium⁽⁰⁾*CHCl₃; (1R,2R)-(+)-1,2-[NHC(O)(o-(PPh₂)C₆H₄]2-cyclohexane / tetrahydrofuran / -50 - 20 °C

3: 98 percent / KOH / methanol / 2 h / 70 °C

4: 99 percent / K₂CO₃ / dimethylformamide / 20 °C

5: 98 percent / 2,6-lutidine / CH₂Cl₂ / 20 °C

6: 98 percent / Cl₂(PCy₃)2RuCHPh; ethylene; Pb(OAc)4 / CH₂Cl₂ / 14 h / 20 °C

7: tetrahydrofuran / 8 h / 0 - 55 °C

8: 2.19 g / aq. NaOH; aq. H₂O₂ / ethanol / 1 h / Heating

With 2,6-dimethylpyridine; lead(IV) acetate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium hydroxide; sodium hydroxide; Grubbs catalyst first generation; ethene; dihydrogen peroxide; potassium carbonate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo025589u