3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

Base Information

Chemical Name:3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline
CAS No.:1376918-75-0
Molecular Formula:C₂₄H₂₀ClN₅
Molecular Weight:413.909
Hs Code.:

Synonyms:3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

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Chemical Property of 3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

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Technology Process of 3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

There total 11 articles about 3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₁₈ClN₅

: 1376918-75-0
3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.03.077

Reference yield:

: 110522-03-7
6-chloro-9H-β-carboline-3-carboxylic acid methyl ester

: 1376918-75-0
3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

Guidance literature:: Multi-step reaction with 11 steps

1: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere

2: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere

3: acetic acid / water / 1 h / Reflux; Inert atmosphere

4: chloroform / 0.5 h / 40 °C / Inert atmosphere

5: sodium nitrate; trifluoroacetic acid / 18 h / 0 - 20 °C / Inert atmosphere

6: hydrogenchloride / water / 12 h / Reflux; Inert atmosphere

7: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere

8: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

9: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere

10: acetic acid / methanol / 5 h / 20 °C / pH 4 / Inert atmosphere

11: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium nitrate; tin(II) chloride dihdyrate; sodium cyanoborohydride; hydrazine hydrate; acetic acid; trifluoroacetic acid; sodium nitrite; In methanol; pentan-1-ol; chloroform; water; 3: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.03.077

Reference yield:

: C₁₈H₁₁ClN₄O₂

: 1376918-75-0
3-benzylamino-6-chloro-8-(pyridin-3-ylmethyl)amino-9H-β-carboline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

2: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere

3: acetic acid / methanol / 5 h / 20 °C / pH 4 / Inert atmosphere

4: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; sodium cyanoborohydride; acetic acid; In methanol; water;
DOI:10.1016/j.bmcl.2012.03.077