4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Base Information

Chemical Name:4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide
CAS No.:1619983-96-8
Molecular Formula:C₃₀H₄₅F₃N₄O₂
Molecular Weight:550.708
Hs Code.:

Synonyms:4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

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Chemical Property of 4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

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Technology Process of 4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

There total 12 articles about 4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 455-24-3
4-trifluoromethylbenzoic acid

: 1619984-63-2
C₂₂H₄₂N₄O

: 1619983-96-8
4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 468-68-8
(-)-drimenol

: 1619983-96-8
4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Reflux

3.1: 2-iodoxybenzoic acid / acetonitrile / 3.5 h / 75 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / Reflux

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; ammonium formate / methanol; ethyl acetate / 18 h / Reflux; Inert atmosphere

7.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

9.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

10.1: dimethyl sulfoxide / 16 h / 60 °C / Inert atmosphere

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere; Reflux

11.2: 1 h / 0 - 20 °C

12.1: dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; borane-THF; 2-iodoxybenzoic acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1619984-47-2
C₃₁H₄₆O₂Si

: 1619983-96-8
4-methyl-N-((2R,3S,4S,4aR)-3,4a,8,8-tetramethyl-4-(2-(4-(trifluoromethyl)benzamido)ethyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2-iodoxybenzoic acid / acetonitrile / 3.5 h / 75 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / Reflux

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; ammonium formate / methanol; ethyl acetate / 18 h / Reflux; Inert atmosphere

5.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

7.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

8.1: dimethyl sulfoxide / 16 h / 60 °C / Inert atmosphere

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere; Reflux

9.2: 1 h / 0 - 20 °C

10.1: dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; 2-iodoxybenzoic acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;