diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate

Base Information

• Chemical Name: diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate
• CAS No.: 77312-71-1
• Molecular Formula: C₂₂H₂₆O₆
• Molecular Weight: 386.445
• Mol file: 77312-71-1.mol

Synonyms:diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate

Chemical Property of diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate

There total 2 articles about diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl bromide (100-39-0) + diethyl tartrate (21066-72-8) → diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate (77312-71-1)

Guidance literature:

With potassium iodide; silver(l) oxide; In dichloromethane; for 1h; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01898

Reference yield: 87.0%

diethyl (2R,3R)-tartrate (87-91-2) + benzyl bromide (100-39-0) → diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate (77312-71-1)

Guidance literature:

With silver(l) oxide; In acetonitrile; at 20 ℃; Darkness;

DOI:10.1039/c3ra43232g

Reference yield: 100.0%

diethyl (2R,3R)-2,3-bis(benzyloxy)butane-1,4-dioate (77312-71-1) → (2R,3R)-2,3-Bis-benzyloxy-succinamide (133519-75-2)

Guidance literature:

With ammonia; In methanol; for 240h; Ambient temperature;

upstream raw materials:

diethyl (2R,3R)-tartrate

benzyl bromide

diethyl tartrate

Downstream raw materials:

(2R,3R)-2,3-bis(benzyloxy)tartaric acid

(2R,3R)-2,3-Bis-benzyloxy-succinamide

1,4-di-O-benzyl-L-threitol

(2R,3S)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butanal