(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

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Chemical Name:(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate
CAS No.:1000045-68-0
Molecular Formula:C₄H₄O₄*C₂₉H₅₂N₄O₆
Molecular Weight:668.828
Hs Code.:

(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

Synonyms:(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

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Chemical Property of (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

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Technology Process of (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

There total 9 articles about (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 1000045-68-0
(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 16 h / 20 °C / Cooling with ice

2: toluene / 1.5 h / 110 °C

3: 2-hydroxypyridin; triethylamine / 2 h / 80 °C

4: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5: methanol / 0.08 h / 20 °C

With 2-hydroxypyridin; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; thiophenol; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-11-12224

Reference yield:

: 1000045-29-3
N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

: 1000045-68-0
(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 °C

2: toluene / 1.5 h / 110 °C

3: 2-hydroxypyridin; triethylamine / 2 h / 80 °C

4: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5: methanol / 0.08 h / 20 °C

With 2-hydroxypyridin; caesium carbonate; thiophenol; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 1: Mitsunobu reaction;
DOI:10.3987/COM-11-12224

Reference yield:

: C₁₆H₂₁N₃O₃

: 1000045-68-0
(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; ethanol / 6 h / 20 °C

2: triethylamine / tetrahydrofuran; water / 12 h / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 °C

4: toluene / 1.5 h / 110 °C

5: 2-hydroxypyridin; triethylamine / 2 h / 80 °C

6: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

7: methanol / 0.08 h / 20 °C

With 2-hydroxypyridin; hydrogenchloride; palladium 10% on activated carbon; hydrogen; caesium carbonate; thiophenol; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;
DOI:10.3987/COM-11-12224