N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide
• CAS No.: 1000045-29-3
• Molecular Formula: C₁₅H₂₀N₂O₇S
• Molecular Weight: 372.399

Synonyms:N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

Chemical Property of N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

There total 10 articles about N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,5S)-5-[(S)-1-amino-2-hydroxyethyl]-3-isopropyltetrahydrofuran-2-one hydrochloride (1000045-30-6) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide (1000045-29-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 12h;

Reference yield:

C9H17NO3 (1000146-73-5) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide (1000045-29-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2013.03.022

Reference yield:

C9H17NO3 + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide (1000045-29-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 12h;

DOI:10.3987/COM-11-12224

upstream raw materials:

(3S,5S)-5-[(S)-1-amino-2-hydroxyethyl]-3-isopropyltetrahydrofuran-2-one hydrochloride

2-Nitrobenzenesulfonyl chloride

(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

(2S,4E)-6-(benzyloxy)-2-isopropylhex-4-enoic acid

Downstream raw materials:

(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

C₂₉H₅₂N₄O₆

(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate

(2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-(trans-4-hydroxycyclohexyl)-2-isopropylhexanamide fumarate

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