7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Base Information

Chemical Name:7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine
CAS No.:152769-36-3
Molecular Formula:C₄₁H₇₄N₄O₉Si
Molecular Weight:795.145
Hs Code.:

Synonyms:7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Suppliers and Price of 7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

There total 14 articles about 7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N'-dicarbo-tert-butoxythermospermine

: 152769-36-3
7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Guidance literature:: In dichloromethane; at 23 ℃; for 11.5h;
DOI:10.1021/jo00076a017

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 152769-36-3
7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / CH₂Cl₂ / 3.75 h / 23 °C

2: 77 percent / LAH / diethyl ether / 1.5 h / 0 °C

3: 85 percent / CH₂Cl₂ / 0.83 h / 23 °C

4: 68 percent / N-chlorosuccinimide, dimethyl sulfide / toluene / 3.5 h / -25 - -20 °C

5: Na₂SO₄ / ethanol / 20.5 h / 23 °C

6: NaBH₄ / ethanol / 10 h / 23 °C

7: 88 percent / CH₂Cl₂ / 11.5 h / 23 °C

With sodium tetrahydroborate; N-chloro-succinimide; lithium aluminium tetrahydride; dimethylsulfide; sodium sulfate; In diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1021/jo00076a017

Reference yield:

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 152769-36-3
7-<1-<2-<(tert-Butyldimethylsilyl)oxy>ethyl>>-N'''-carbobenzoxy-N,N',N''-tricarbo-tert-butoxythermospermine

Guidance literature:: Multi-step reaction with 12 steps

1: 91 percent / dimethylsulfoxide / 25 h / 23 °C

2: 86 percent / LDA / tetrahydrofuran; cyclohexane / 1.) -78 deg C, 30 min, then 30 min, 2.) -78 deg C, 2 h

3: 66 percent / LiBH₄ / CH₂Cl₂ / 4 h / 23 °C

4: 67 percent / LAH / diethyl ether / 1.) 0 deg C, 1 h, 2.) r.t., 3.5 h

5: 83 percent / methanol / 24 h / 23 °C

6: 99 percent / CH₂Cl₂ / 3.75 h / 23 °C

7: 77 percent / LAH / diethyl ether / 1.5 h / 0 °C

8: 85 percent / CH₂Cl₂ / 0.83 h / 23 °C

9: 68 percent / N-chlorosuccinimide, dimethyl sulfide / toluene / 3.5 h / -25 - -20 °C

10: Na₂SO₄ / ethanol / 20.5 h / 23 °C

11: NaBH₄ / ethanol / 10 h / 23 °C

12: 88 percent / CH₂Cl₂ / 11.5 h / 23 °C

With sodium tetrahydroborate; N-chloro-succinimide; lithium aluminium tetrahydride; lithium borohydride; dimethylsulfide; sodium sulfate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; cyclohexane; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00076a017