Technology Process of C17H18BF3N2O2
There total 1 articles about C17H18BF3N2O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate;
In
water; N,N-dimethyl-formamide;
at 75 ℃;
for 3h;
DOI:10.1016/j.bmcl.2013.12.090
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate;
In
1,2-dimethoxyethane; water;
at 80 ℃;
for 1h;
DOI:10.1016/j.bmcl.2013.12.090
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,2-dimethoxyethane; water / 1 h / 80 °C
2.1: C3H7ClMg*Li(1+)*Cl(1-) / 1 h / -45 °C
2.2: 0.5 h / -20 °C
2.3: 1 h / -40 - -20 °C
3.1: toluene-4-sulfonic acid / toluene / 7 h / 100 °C
4.1: Raney Ni / ethanol / 3 h / 100 °C
5.1: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 25 °C
6.1: 1,2-dichloro-ethane; triethylamine; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 25 °C
7.1: sodium hydroxide / Resolution of racemate
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; 1-hydroxy-7-aza-benzotriazole; C3H7ClMg*Li(1+)*Cl(1-); toluene-4-sulfonic acid; 1,2-dichloro-ethane; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2013.12.090
