(1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

Base Information

Chemical Name:(1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol
CAS No.:229010-43-9
Molecular Formula:C₂₀H₃₈O₂Si
Molecular Weight:338.606
Hs Code.:

Synonyms:(1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

Suppliers and Price of (1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

Chemical Property:

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Technology Process of (1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

There total 7 articles about (1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 229010-42-8
(1S,2S,4R,5R)-2-(2-Hydroxy-ethyl)-4-isopropenyl-5-methyl-5-vinyl-cyclohexanol

: 229010-43-9
(1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1h;
DOI:10.1039/a809983i

Reference yield:

: 149404-74-0
(4R,5R)-1-Acetoxy-4-isopropenyl-5-methyl-5-vinylcyclohex-1-ene

: 229010-43-9
(1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / K₂CO₃ / methanol

2: LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 4 h

3: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / -50 °C

4: 87 percent / imidazole / dimethylformamide / 1 h

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1039/a809983i

Reference yield:

: 149404-72-8
(3R,4R)-3-Methyl-4-isopropenyl-3-vinylcyclohexanone

: 229010-43-9
(1S,2S,4R,5R)-2-<2-(tert-Butyldimethylsilyloxy)ethyl>-4-isopropenyl-5-methyl-5-vinylcyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 4 h

2: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / -50 °C

3: 87 percent / imidazole / dimethylformamide / 1 h

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/a809983i