4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

Base Information

Chemical Name:4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde
CAS No.:1240468-79-4
Molecular Formula:C₁₉H₁₂F₂N₄O
Molecular Weight:350.327
Hs Code.:

Synonyms:4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

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Chemical Property of 4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

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Technology Process of 4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

There total 1 articles about 4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1240468-82-9
5-chloro-6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

: 87199-17-5
4-formylphenylboronic acid,

: 1240468-79-4
4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; at 90 ℃; for 2h; Inert atmosphere;

Reference yield: 28.7%

: 2-methyl-6-(5-piperidine-4-yl-2H-[1,2,4]triazole-3-yl)-pyridine dihydrochloride

: 1240468-79-4
4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

: 1240468-31-8
6-(2,4-difluorophenyl)-2-methyl-5-(4-{4-[5-(6-methylpyridine-2-yl)-1H-[1,2,4]triazole-3-yl]-piperidine-1-ylmethyl}-phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: 2-methyl-6-(5-piperidine-4-yl-2H-[1,2,4]triazole-3-yl)-pyridine dihydrochloride; With triethylamine; In 1-methyl-pyrrolidin-2-one; for 1h;

4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde; With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield: 27.6%

: 1240468-79-4
4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde

: 4-chloro-2-(5-piperidine-4-yl-2H-[1,2,4]triazole-3-yl)-pyridine dihydrochloride

: 1240468-30-7
5-(4-{4-[5-(4-chloropyridine-2-yl)-1H-[1,2,4]triazole-3-yl]-piperidine-1-ylmethyl}-phenyl)-6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: 4-chloro-2-(5-piperidine-4-yl-2H-[1,2,4]triazole-3-yl)-pyridine dihydrochloride; With triethylamine; In 1-methyl-pyrrolidin-2-one; for 1h;

4-[6-(2,4-difluorophenyl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde; With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃;