(4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

Base Information

Chemical Name:(4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide
CAS No.:1069087-66-6
Molecular Formula:C₁₄H₁₅ClF₃N₃O₂
Molecular Weight:349.74
Hs Code.:

Synonyms:(4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

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Chemical Property of (4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

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Technology Process of (4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

There total 4 articles about (4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1069090-20-5
(S)-1,3-dimethyl-2-oxo-4-imidazolidinecarboxylic acid

: 39226-96-5
2-chloro-3-(trifluoromethyl)benzylamine

: 1069087-66-6
(4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2010.09.101

Reference yield:

: 90242-55-0
Methyl (4S)-3-<(benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

: 1069087-66-6
(4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 24 h

2: sodium hydride / N,N-dimethyl-formamide / 18.33 h / -10 - 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 4 h / 0 - 5 °C

4: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 22 °C

With N-ethylmorpholine;; lithium hydroxide; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1069090-18-1
methyl (S)-1,3-dimethyl-2-oxo-4-imidazolidinecarboxylate

: 1069087-66-6
(4S)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-dimethyl-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran / 4 h / 0 - 5 °C

2: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 22 °C

With N-ethylmorpholine;; lithium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;