Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

Base Information

Chemical Name:Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester
CAS No.:182164-69-8
Molecular Formula:C₃₄H₃₆F₂O₁₀P₂
Molecular Weight:704.598
Hs Code.:

Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

Synonyms:Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

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Chemical Property of Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

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Technology Process of Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

There total 6 articles about Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 182164-68-7
C₄₀H₄₄F₂O₁₀P₂

: 182164-69-8
Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at -20 ℃; for 4h;
DOI:10.1039/cc9960001815

Reference yield:

: 115509-74-5
1⁽³⁾,2-O-cyclohexylidene-3⁽¹⁾,6⁽⁴⁾-di-O-benzyl-sn-myoinositol

: 182164-69-8
Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrazole

2: MCPBA

3: PhSH, Et₃N / 2 h / Ambient temperature

4: 2-fluoro-1-methylpyridinium tosylate, Et₃N / 4 h / Ambient temperature

5: 68 percent / CF₃CO₂H / CH₂Cl₂ / 4 h / -20 °C

With 1H-tetrazole; 1-methyl-2-fluoropyridinium p-toluenesulfonate; thiophenol; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/cc9960001815

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 182164-69-8
Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrazole

2: MCPBA

3: PhSH, Et₃N / 2 h / Ambient temperature

4: 2-fluoro-1-methylpyridinium tosylate, Et₃N / 4 h / Ambient temperature

5: 68 percent / CF₃CO₂H / CH₂Cl₂ / 4 h / -20 °C

With 1H-tetrazole; 1-methyl-2-fluoropyridinium p-toluenesulfonate; thiophenol; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/cc9960001815