Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

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Chemical Name:Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester
CAS No.:182164-70-1
Molecular Formula:C₄₈H₄₉F₂O₁₃P₃
Molecular Weight:964.827
Hs Code.:

Synonyms:Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

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Chemical Property of Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

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Technology Process of Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

There total 7 articles about Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 15205-57-9
tribenzyl phosphite

: 182164-69-8
Phosphorofluoridic acid benzyl ester (1R,2S,3S,4R,5S,6R)-2,5-bis-benzyloxy-6-(benzyloxy-fluoro-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

: 182164-70-1
Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

Guidance literature:: With pyridinium hydrobromide perbromide; triethylamine; at 0 ℃; for 0.5h;
DOI:10.1039/cc9960001815

Reference yield:

: 115509-74-5
1⁽³⁾,2-O-cyclohexylidene-3⁽¹⁾,6⁽⁴⁾-di-O-benzyl-sn-myoinositol

: 182164-70-1
Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrazole

2: MCPBA

3: PhSH, Et₃N / 2 h / Ambient temperature

4: 2-fluoro-1-methylpyridinium tosylate, Et₃N / 4 h / Ambient temperature

5: 68 percent / CF₃CO₂H / CH₂Cl₂ / 4 h / -20 °C

6: 68 percent / PyHBr₃, Et₃N / 0.5 h / 0 °C

With 1H-tetrazole; 1-methyl-2-fluoropyridinium p-toluenesulfonate; thiophenol; pyridinium hydrobromide perbromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/cc9960001815

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 182164-70-1
Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(benzyloxy-fluoro-phosphoryloxy)-6-hydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrazole

2: MCPBA

3: PhSH, Et₃N / 2 h / Ambient temperature

4: 2-fluoro-1-methylpyridinium tosylate, Et₃N / 4 h / Ambient temperature

5: 68 percent / CF₃CO₂H / CH₂Cl₂ / 4 h / -20 °C

6: 68 percent / PyHBr₃, Et₃N / 0.5 h / 0 °C

With 1H-tetrazole; 1-methyl-2-fluoropyridinium p-toluenesulfonate; thiophenol; pyridinium hydrobromide perbromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/cc9960001815