7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester
CAS No.:1309459-65-1
Molecular Formula:C₃₂H₅₃N₅O₈
Molecular Weight:635.802
Hs Code.:

Synonyms:7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

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Chemical Property of 7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

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Technology Process of 7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

There total 8 articles about 7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258945-73-1
[1-formyl-4-(4-nitrophenyl)butyl]carbamic acid tert-butyl ester

: 174138-01-3
1,4-di-tert-butyl 1,4,7-triazonane-1,4-dicarboxylate

: 1309459-65-1
7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 24h;
DOI:10.1039/c0cc05707j

Reference yield:

: 1142811-85-5
2-Amino-5-(4-nitrophenyl)-pentan-1-ol

: 1309459-65-1
7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 4.33 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -60 - -50 °C

2.2: -60 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C

With oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In dichloromethane; 1,2-dichloro-ethane; acetonitrile; 2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1039/c0cc05707j

Reference yield:

: 1206716-20-2
2-amino-5-(4-nitrophenyl)pentanoic acid

: 1309459-65-1
7-[2-tert-butoxycarbonylamino-5-(4-nitrophenyl)pentyl]-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 0 - 20 °C

2.1: triethylamine / methanol; diethyl ether / 1 h / -10 °C

3.1: sodium tetrahydroborate / methanol / 0 - 20 °C

4.1: acetonitrile / 4.33 h / 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -60 - -50 °C

5.2: -60 - 20 °C

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile; 5.1: Swern oxidation / 5.2: Swern oxidation;
DOI:10.1039/c0cc05707j