1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

Base Information

Chemical Name:1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one
CAS No.:78738-82-6
Molecular Formula:C₂₃H₂₆N₂O₃
Molecular Weight:378.471
Hs Code.:

Synonyms:1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

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Chemical Property of 1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

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Technology Process of 1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

There total 15 articles about 1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-52-7
benzaldehyde

: 83049-24-5
(S)-2-((3S,4R)-3-Amino-2-oxo-4-phenyl-azetidin-1-yl)-propionic acid tert-butyl ester

: 78688-68-3,78738-82-6
(S)-2-((3S,4R)-2-Oxo-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-1-yl)-propionic acid tert-butyl ester

Guidance literature:: With magnesium sulfate; In benzene;
DOI:10.1039/c39810000344

Reference yield: 96.0%

: 100-52-7
benzaldehyde

: 83198-12-3
(S)-2-((3R,4S)-3-Amino-2-oxo-4-phenyl-azetidin-1-yl)-propionic acid tert-butyl ester

: 78688-68-3,78738-82-6
(S)-2-((3R,4S)-2-Oxo-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-1-yl)-propionic acid tert-butyl ester

Guidance literature:: With magnesium sulfate; In benzene;
DOI:10.1039/c39810000344

Reference yield:

: 21691-50-9
Ala-OtBu

: 78738-82-6
1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / sodium sulfate / benzene / 14 h / Ambient temperature

2: 41 percent / triethylamine / CH₂Cl₂ / 14 h / -78 deg C to room temperature

3: 96 percent / H₂ / 5 percent Pd-C / methanol / 6 h / 0 - 5 °C

4: magnesium sulfate / benzene / 17 h / Ambient temperature

With hydrogen; magnesium sulfate; sodium sulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; benzene;
DOI:10.1021/ja00240a033