(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

Base Information

Chemical Name:(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate
CAS No.:171827-03-5
Molecular Formula:C₂₁H₃₀O₈
Molecular Weight:410.464
Hs Code.:

Synonyms:(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

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Chemical Property of (E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

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Technology Process of (E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

There total 9 articles about (E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 171827-00-2
(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

: 171827-03-5
(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

Guidance literature:: With sodium dihydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 5.25h;
DOI:10.1021/jm9501339

Reference yield:

: 31456-95-8
Methyl 4-methoxy-2-(prop-2-enyloxy)benzoate

: 171827-03-5
(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / 3 h / 210 °C

2: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 30 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 30 min

3: 89 percent / benzene / 28.5 h / Heating

4: 1.) NaH / 1.) THF, 0 deg C, 40 min, 2.) THF, a) 0 deg C, 15 min, b) 25 deg C, 25 h

5: 91 percent / NaBH₄ / methanol / 4.5 h

6: 85 percent / N,N-diisopropylethylamine, CBr₄, Ph₃P / CH₂Cl₂ / 19 h

7: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 18 h

8: 81 percent / Na(Hg), NaH₂PO₄ / methanol / 5.25 h / 0 °C

With methanol; sodium tetrahydroborate; sodium dihydrogenphosphate; sodium amalgam; carbon tetrabromide; sodium hydride; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; benzene;
DOI:10.1021/jm9501339

Reference yield:

: 31457-00-8
methyl 3-allyl-2-hydroxy-4-methoxybenzoate

: 171827-03-5
(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxyphenyl>>-4-hexenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 30 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 30 min

2: 89 percent / benzene / 28.5 h / Heating

3: 1.) NaH / 1.) THF, 0 deg C, 40 min, 2.) THF, a) 0 deg C, 15 min, b) 25 deg C, 25 h

4: 91 percent / NaBH₄ / methanol / 4.5 h

5: 85 percent / N,N-diisopropylethylamine, CBr₄, Ph₃P / CH₂Cl₂ / 19 h

6: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 18 h

7: 81 percent / Na(Hg), NaH₂PO₄ / methanol / 5.25 h / 0 °C

With methanol; sodium tetrahydroborate; sodium dihydrogenphosphate; sodium amalgam; carbon tetrabromide; sodium hydride; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; benzene;
DOI:10.1021/jm9501339