31456-95-8

Upstream product

• 5446-02-6 4-methoxymethylsalicylate 
• 107-05-1 3-chloroprop-1-ene 
• 2237-36-7 4-methoxysalicylic acid 
• 106-95-6 allyl bromide 

Downstream Products

• 31457-00-8 methyl 3-allyl-2-hydroxy-4-methoxybenzoate 
• 668455-70-7 2-(allyloxy)-4-methoxybenzoic acid 
• 165258-18-4 N,N-Diethyl-4-methoxy-2-(prop-2-enyloxy)benzamide 
• 5446-02-6 4-methoxymethylsalicylate 
• 71186-58-8 2-allyloxy-4-methoxybenzaldehyde 
• 1207288-79-6 methyl 3-(2-(allyloxy)-4-methoxyphenyl)propiolate 
• 1207288-78-5 2-(allyloxy)-1-(2,2-dibromovinyl)-4-methoxybenzene 
• 1207288-77-4 (2-(allyloxy)-4-methoxyphenyl)methanol 
• 1207288-80-9 3-(2-(allyloxy)-4-methoxyphenyl)propiolic acid 
• 13677-76-4 2-allyl-5-methoxyphenol 
• 165258-33-3 N,N-Diethyl-2-<(tert-butyldimethylsilyl)oxy>-6-formyl-4-methoxy-5-methyl-3-(prop-2-enyl)benzamide 
• 165258-34-4 N,N-Diethyl-2-<(tert-butyldimethylsilyl)oxy>-6-hydroxymethyl-4-methoxy-5-methyl-3-(prop-2-enyl)benzamide 
• 165258-28-6 N,N-Diethyl-2-<(tert-butyldimethylsilyl)oxy>-6-deutero-4-methoxy-3-(prop-2-enyl)benzamide 
• 165258-26-4 N,N-Diethyl-5-bromo-6-deutero-2-(methoxy-d3)-4-methoxy-3-(prop-2-enyl)benzamide 

Relevant academic research and scientific papers

Oxidative cyclization of alkenoic acids promoted by AgOAc

Alkenoic acids derived from salicylic acid and analogues undergo an unexpected oxidative cyclization process triggered by AgOAc leading to 4H-benzo[d][1,3]dioxin-4-ones. The process is affected by the substitution on the aryl and the allyl units.

Palladium-catalyzed intramolecular carboesterification of olefins

One catalyst three bonds: The title reaction between propiolic acids and unactivated olefins (see scheme; O red, Cl green) results in vicinal functionalization of the olefin, with the formation of new C-C and C-O bonds. Structurally complex 6,7,5-tricyclic ring systems are formed in a single step by this cascade chloropalladation and formal [3+2] cycloaddition.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Synthesis and modeling studies with monocyclic analogues of mycophenolic acid

Two stepwise procedures, developed for the introduction of the (E)-4- methyl-4-hexenoic acid side chain of mycophenolic acid, were used in the synthesis of monocyclic mycophenolic acid analogues 2a-i. The derivatives with a methyl group or hydrogen at C-4 and lacking the lactone moiety were much less cytotoxic than mycophenolic acid. The menocyclic analogues with a C-4 chloro group did show some activity, albeit much less than mycophenolic acid. The observed differences in potency are rationalized by semiempirical calculations of intramolecular H-bonds.

The Synthesis of Mycophenolic Acid from 2,4-Dihydroxybenzoic Acid

Mycophenolic acid (1) has been synthesized from 2,4-dihydroxybenzoic acid by regioselective introduction of the three required carbon substituents.A key transformation in this sequence is the introduction of the methyl substituent at position 5 by a rapid, uncatalyzed replacement of the bromide in 8 at low temperature by methyllithium.The scope and mechanism of this methylation reaction are examined.