(R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine

Base Information

• Chemical Name: (R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine
• CAS No.: 918160-15-3
• Molecular Formula: C₂₆H₂₄N₂O₄S
• Molecular Weight: 460.554
• Mol file: 918160-15-3.mol

Synonyms:(R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine

Chemical Property of (R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine

There total 1 articles about (R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-Dimethoxybenzhydrol (728-87-0) → (R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine (918160-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / acetyl bromide / benzene / 1 h / 20 °C

2: 89 percent / NaH / tetrahydrofuran; various solvent(s) / 0 °C

With Acetyl bromide; sodium hydride; In tetrahydrofuran; benzene;

DOI:10.1021/ja0640142

Reference yield: 98.0%

(R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine (918160-15-3) + benzyl bromide (100-39-0) → (R)-(+)-10-di(p-anisyl)methyl-11a-benzyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine

Guidance literature:

(R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine; benzyl bromide; In tetrahydrofuran; at -100 ℃; for 0.25h;

With potassium hexamethylsilazane; In tetrahydrofuran; hexane; at -100 ℃;

DOI:10.1021/ja0640142

Reference yield:

(R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine (918160-15-3) + allyl bromide (106-95-6) → (11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine + (11aS)-11a-allyl-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine

Guidance literature:

(R)-(+)-10-di(p-anisyl)methyl-5,10,11,11a-tetrahydro-5,11-dioxo-1H,3H-[1,3]thiazolo[4,3-c][1,4]benzodiazepine; allyl bromide; In tetrahydrofuran; at -100 ℃; for 0.25h;

With potassium hexamethylsilazane; In tetrahydrofuran; hexane; at -100 ℃; Title compound not separated from byproducts;

DOI:10.1021/ja0640142

upstream raw materials:

4,4'-Dimethoxybenzhydrol