6-Hydroxy-heptane acid phenylester

Base Information

• Chemical Name: 6-Hydroxy-heptane acid phenylester
• CAS No.: 166273-40-1
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 166273-40-1.mol

Synonyms:6-Hydroxy-heptane acid phenylester

Chemical Property of 6-Hydroxy-heptane acid phenylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 6-Hydroxy-heptane acid phenylester

There total 4 articles about 6-Hydroxy-heptane acid phenylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-Oxoheptane acid phenylester (166273-39-8) → 6-Hydroxy-heptane acid phenylester (166273-40-1)

Guidance literature:

With sodium tetrahydroborate; In diethyl ether; water; isopropyl alcohol; -20 deg C to r.t.;

Reference yield: 75.0%

phenyl acrylate (937-41-7) + toluene-4-sulfonic acid 3-hydroxybutyl ester (59744-08-0) → 6-Hydroxy-heptane acid phenylester (166273-40-1)

Guidance literature:

With manganese; chloro-trimethyl-silane; vitamin B₁₂; triethylamine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Irradiation; Schlenk technique; Inert atmosphere;

DOI:10.1039/d0ra10739e

Reference yield:

6-oxoheptanoic acid (3128-07-2) → 6-Hydroxy-heptane acid phenylester (166273-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / SOCl₂ / 0.5 h / Heating

2: 85 percent / pyridine / toluene

3: 81 percent / NaBH₄ / diethyl ether; propan-2-ol; H₂O / -20 deg C to r.t.

With pyridine; sodium tetrahydroborate; thionyl chloride; In diethyl ether; water; isopropyl alcohol; toluene;

upstream raw materials:

6-Oxoheptane acid phenylester

6-oxoheptanoic acid

6-oxoheptanoic acid chloride

phenyl acrylate