6-Oxoheptane acid phenylester

Base Information

• Chemical Name: 6-Oxoheptane acid phenylester
• CAS No.: 166273-39-8
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Mol file: 166273-39-8.mol

Synonyms:6-Oxoheptane acid phenylester

Chemical Property of 6-Oxoheptane acid phenylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Oxoheptane acid phenylester

There total 3 articles about 6-Oxoheptane acid phenylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-oxoheptanoic acid chloride (56721-54-1) + phenol (108-95-2,27073-41-2) → 6-Oxoheptane acid phenylester (166273-39-8)

Guidance literature:

With pyridine; In toluene;

Reference yield:

n-hexan-2-one (591-78-6) + phenyl chloroformate (1885-14-9) → phenyl 2-ethyl-4-oxopentanoate + phenyl 2-methyl-5-oxohexanoate + 6-Oxoheptane acid phenylester (166273-39-8)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium tungstate (VI) dihydrate; phosphate potassium salt; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; In benzene; at 40 ℃; for 48h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.8b09191

Reference yield:

6-oxoheptanoic acid (3128-07-2) → 6-Oxoheptane acid phenylester (166273-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / SOCl₂ / 0.5 h / Heating

2: 85 percent / pyridine / toluene

With pyridine; thionyl chloride; In toluene;

upstream raw materials:

6-oxoheptanoic acid chloride

phenol

6-oxoheptanoic acid

n-hexan-2-one

Downstream raw materials:

6-Hydroxy-heptane acid phenylester