4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

Base Information

Chemical Name:4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine
CAS No.:1288999-18-7
Molecular Formula:C₂₂H₂₄IN₅O₅
Molecular Weight:565.368
Hs Code.:

Synonyms:4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

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Chemical Property of 4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

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Technology Process of 4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

There total 3 articles about 4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1288998-80-0
4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-2'-deoxycytidine

: 107-13-1,25014-41-9
acrylonitrile

: 1288999-18-7
4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; tert-butyl alcohol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201001952

Reference yield:

: 717876-93-2
N'-[1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-iodo-2-oxo-1,2-dihydro-pyrimidin-4-yl]-N,N-dimethyl-formamidine

: 1288999-18-7
4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

With caesium carbonate; In pyridine; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/chem.201001952

Reference yield:

: 611-53-0
5-Iodo-2'-deoxycytidine

: 1288999-18-7
4-N-(N,N-dimethylaminomethylidenyl)-5-iodo-5'-O-benzoyl-3'-O-(2-cyanoethyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 2.5 h / 55 °C

2: pyridine; N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

With caesium carbonate; In pyridine; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/chem.201001952