4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester

Base Information

• Chemical Name: 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester
• CAS No.: 869892-70-6
• Molecular Formula: C₁₅H₁₈O₆S
• Molecular Weight: 326.37
• Mol file: 869892-70-6.mol

Synonyms:4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester

Chemical Property of 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester

There total 3 articles about 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-bromomethyl-3-(1-methoxycarbonyl-ethoxy)benzoic acid methyl ester (869892-68-2) + potassium thioacetate (10387-40-3) → 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester (869892-70-6)

Guidance literature:

In N,N-dimethyl-formamide; at 22 ℃; for 24h;

DOI:10.1039/b510633h

Reference yield:

3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester (869892-67-1) → 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester (869892-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / NBS; AIBN / benzene / 24 h / 85 °C

2: 98 percent / dimethylformamide / 24 h / 22 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide; benzene;

DOI:10.1039/b510633h

Reference yield:

methyl 4-methyl-3-hydroxybenzoate (3556-86-3) → 4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester (869892-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃; NaI / acetone / 16 h / 70 °C

2: 64 percent / NBS; AIBN / benzene / 24 h / 85 °C

3: 98 percent / dimethylformamide / 24 h / 22 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone; benzene;

DOI:10.1039/b510633h

upstream raw materials:

4-bromomethyl-3-(1-methoxycarbonyl-ethoxy)benzoic acid methyl ester

potassium thioacetate

3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester

methyl 4-methyl-3-hydroxybenzoate