3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester

Base Information

• Chemical Name: 3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester
• CAS No.: 869892-67-1
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267
• Mol file: 869892-67-1.mol

Synonyms:3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester

Chemical Property of 3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester

There total 2 articles about 3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Methyl 2-bromopropionate (5445-17-0) + methyl 4-methyl-3-hydroxybenzoate (3556-86-3) → 3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester (869892-67-1)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; at 70 ℃; for 16h;

DOI:10.1039/b510633h

Reference yield:

3-hydroxy-4-methylbenzoic acid (586-30-1) → 3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester (869892-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / 16 h / Heating

2: 78 percent / K₂CO₃; NaI / acetone / 16 h / 70 °C

With thionyl chloride; potassium carbonate; sodium iodide; In acetone;

DOI:10.1039/b510633h

Reference yield: 100.0%

3-(1-methoxycarbonyl-ethoxy)-4-methylbenzoic acid methyl ester (869892-67-1) → 3-(1-carboxy-ethoxy)-4-methyl-benzoic acid

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 40 ℃; for 2h;

DOI:10.1039/b510633h

upstream raw materials:

Methyl 2-bromopropionate

methyl 4-methyl-3-hydroxybenzoate

3-hydroxy-4-methylbenzoic acid

Downstream raw materials:

4-bromomethyl-3-(1-methoxycarbonyl-ethoxy)benzoic acid methyl ester

4-azidomethyl-3-(1-methoxycarbonyl-ethoxy)benzoic acid methyl ester

4-acetylsulfanylmethyl-3-(1-methoxycarbonyl-ethoxy)-benzoic acid methyl ester