4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

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Chemical Name:4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
CAS No.:1614231-82-1
Molecular Formula:C₁₈H₁₇BrClF₃N₂O₂
Molecular Weight:465.697
Hs Code.:

Synonyms:4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

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Chemical Property of 4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

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Technology Process of 4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

There total 5 articles about 4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1614231-68-3
4-bromo-2-(α-ethoxy-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

: 3188-13-4
ethyl chloromethyl ether

: 1614231-82-1
4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: 4-bromo-2-(α-ethoxy-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

ethyl chloromethyl ether; In tetrahydrofuran; for 2.5h; Reflux;
DOI:10.1021/jf501377t DOI:10.1021/jf501377t

Reference yield:

: 1614231-61-6
C₁₃H₇BrClF₃N₂

: 1614231-82-1
4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 12 h / 20 °C / Reflux

2.1: sodium carbonate / 1 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

3.2: 2.5 h / Reflux

With sodium hydride; sodium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jf501377t

Reference yield:

: 1614231-63-8
4-bromo-2-(α-hydroxyl-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

: 1614231-82-1
4-bromo-2-(α-ethoxy-4-chlorobenzyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuryl dichloride / dichloromethane / 8 h / Reflux

2.1: sodium carbonate / 1 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

3.2: 2.5 h / Reflux

With sulfuryl dichloride; sodium hydride; sodium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jf501377t