2-p-fluorophenyl-4-m-methoxyphenylbutyric acid

Base Information

• Chemical Name: 2-p-fluorophenyl-4-m-methoxyphenylbutyric acid
• CAS No.: 101615-08-1
• Molecular Formula: C₁₇H₁₇FO₃
• Molecular Weight: 288.319
• Mol file: 101615-08-1.mol

Synonyms:2-p-fluorophenyl-4-m-methoxyphenylbutyric acid

Chemical Property of 2-p-fluorophenyl-4-m-methoxyphenylbutyric acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-p-fluorophenyl-4-m-methoxyphenylbutyric acid

There total 2 articles about 2-p-fluorophenyl-4-m-methoxyphenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(4-Fluoro-phenyl)-4-(3-methoxy-phenyl)-butyronitrile (190972-21-5) → 2-p-fluorophenyl-4-m-methoxyphenylbutyric acid (101615-08-1)

Guidance literature:

With sulfuric acid; In methanol; for 24h; Heating;

DOI:10.1039/a608338b

Reference yield:

3-methoxyphenethyl bromide (2146-61-4) → 2-p-fluorophenyl-4-m-methoxyphenylbutyric acid (101615-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Na / diethyl ether / 1.) reflux, 2 h, 2.) overnight; C₆H₆, reflux, 48 h

2: 66 percent / H₂SO₄ / methanol / 24 h / Heating

With sulfuric acid; sodium; In methanol; diethyl ether;

DOI:10.1039/a608338b

Reference yield: 80.0%

2-p-fluorophenyl-4-m-methoxyphenylbutyric acid (101615-08-1) → 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one (101615-10-5)

Guidance literature:

With hydrogen fluoride;

DOI:10.1039/a608338b

upstream raw materials:

2-(4-Fluoro-phenyl)-4-(3-methoxy-phenyl)-butyronitrile

3-methoxyphenethyl bromide

Downstream raw materials:

2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one