2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one

Base Information

• Chemical Name: 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one
• CAS No.: 101615-10-5
• Molecular Formula: C₁₇H₁₅FO₂
• Molecular Weight: 270.303
• Mol file: 101615-10-5.mol

Synonyms:2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one

Chemical Property of 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one

There total 7 articles about 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-p-fluorophenyl-4-m-methoxyphenylbutyric acid (101615-08-1) → 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one (101615-10-5)

Guidance literature:

With hydrogen fluoride;

DOI:10.1039/a608338b

Reference yield: 77.0%

1-Chloro-4-fluorobenzene (352-33-0) + 6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one (101615-10-5)

Guidance literature:

With C₃₁H₄₃Cl₂N₄Pd; potassium tert-butylate; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c5ob01203a

Reference yield: 15.0%

2-bromo-6-methoxy-1-tetralone (20933-24-8) + 4-flourophenylmagnesium bromide (352-13-6) → 2-p-fluorophenyl-3,4-dihydro-6-methoxy-naphthalen-1(2H)-one (101615-10-5)

Guidance literature:

In diethyl ether; toluene; for 2h; Heating;

DOI:10.1039/a608338b

upstream raw materials:

2-bromo-6-methoxy-1-tetralone

4-flourophenylmagnesium bromide

2-p-fluorophenyl-4-m-methoxyphenylbutyric acid

3-methoxyphenethyl bromide