9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one

Base Information

• Chemical Name: 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one
• CAS No.: 5964-48-7
• Molecular Formula: C₁₆H₁₃FN₂O
• Molecular Weight: 268.29
• Mol file: 5964-48-7.mol

Synonyms:9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one

Chemical Property of 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one

There total 3 articles about 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.5%

2-(4-fluorobenzoyl)benzoic acid (7649-92-5) + ethylenediamine (107-15-3,85404-18-8) → 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (5964-48-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 4h; Dean-Stark; Inert atmosphere; Reflux;

DOI:10.1021/jm4013246

Reference yield:

→ 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (5964-48-7)

Guidance literature:

2-<4-Fluor-benzoyl>-benzoesaeure, Ethylendiamin (3mol), Toluol, Siedehitze;

DOI:10.1021/jo01282a022

Reference yield:

→ 1-(p-fluorophenyl)-1,2,3,4,5,6-hexahydro-2,5-benzodiazocine, dihydrochloride + 9b-(4-fluorophenyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (5964-48-7)

Guidance literature:

upstream raw materials:

2-(4-fluorobenzoyl)benzoic acid

ethylenediamine