ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

Base Information

Chemical Name:ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate
CAS No.:1386935-81-4
Molecular Formula:C₂₇H₃₉ClN₅O₈P
Molecular Weight:628.062
Hs Code.:

Synonyms:ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

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Chemical Property of ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

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Technology Process of ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

There total 3 articles about ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₅ClN₅O₁₁P

: 1386935-81-4
ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

Guidance literature:: With ammonia; In methanol; at 0 - 20 ℃;
DOI:10.1021/jm3004834

Reference yield:

: 1386935-73-4
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

: 1386935-81-4
ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-tetrazole / tetrahydrofuran; dichloromethane / 2 h / 60 °C

2: dihydrogen peroxide / tetrahydrofuran; dichloromethane / 1 h / 0 °C

3: ammonia / methanol / 0 - 20 °C

With 1H-tetrazole; ammonia; dihydrogen peroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm3004834

Reference yield:

: C₃₃H₄₅ClN₅O₁₀P

: 1386935-81-4
ditert-butyl (2-((2-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-3-phenylpropyl) phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide / tetrahydrofuran; dichloromethane / 1 h / 0 °C

2: ammonia / methanol / 0 - 20 °C

With ammonia; dihydrogen peroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm3004834